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Cannabinoids vs COVID-19

The world of hemp and cannabinoid research has already had an exciting start to 2022. In late January, researchers at Oregon State University released their findings on a study surrounding specific cannabinoids blocking the cellular entry of COVID-19 and its variants The study drew the attention of the scientific and medical communities. This information was groundbreaking for several reasons and highlights why cannabinoid research is so important.

According to the PubMed study, (Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants) “Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthostatic ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells.” Researchers focused on two specific cannabinoids in this study, cannabigerolic acid (or CBGA for short) and cannabidiolic acid (or CBDA for short) respectively.

These two cannabinoids have been a focus for research over the past several decades, but this particular study propelled them into the limelight of the scientific community.

What is CBDA?

According to the Recent Advances in Photochemistry, CBDA is the carboxylated form of CBD. First isolated in 1955, “pure CBDA was found to display a potent antimicrobial effect”. 

In an earlier study conducted by researchers at the Cornell University College of Veterinary Medicine, researchers studying the effects of CBDA on dogs found, “The exact functions of CBDA…physiologically suggest similar therapeutic benefits to CBD that may have the potential to work synergistically with CBD.”

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